FLOW CYTOMETRIC ANALYSIS OF THE EFFECT OF ARA-C ON THE CHRONOBIOLOGY OF BONE-MARROW DNA-SYNTHESIS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 8  (4) , 369-373
Abstract
Flow cytometry, a technique which allows rapid quantitation of the percentages of a cell population in the various cell cycle phases, closely duplicated the previously reported circadian rhythm for mouse bone marrow DNA synthesis. The effect of ara-C [cytosine arabinoside], an S phase specific antineoplastic drug, on this rhythm was investigated. Ara-C suppressed this rhythm to a much greater degree when injected at the peak of the bone marrow DNA synthesis as compared to the low. Thus, damage to the bone marrow during treatment with ara-C may be reduced if the circadian rhythm of bone marrow DNA synthesis is taken into account.