The pathogenesis of amiodarone-induced pigmentation and photosensitivity
- 1 April 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 110 (4) , 451-456
- https://doi.org/10.1111/j.1365-2133.1984.tb04660.x
Abstract
A new method was used to measure human tissue levels of amiodarone and its major metabolite desethylamiodarone. Amiodarone-pigmented skin has a drug and metabolite concentration 10 times that of nonpigmented skin. Iodine-rich amiodarone and its metabolite were detected in secondary lysosomes by energy dispersive analysis of X-rays. Amiodarone induces a phototoxic reaction with an action spectrum in both the UV-B and UV-A wavelengths.This publication has 8 references indexed in Scilit:
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