Activation of Human Suppressor Cells in Mixed Lymphocyte Cultures

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Abstract
Lymphocytes transferred from 6-day-old human mixed lymphocyte cultures (MLC) inhibited the response to allogeneic cells of freshly taken lymphocytes autologous to the transferred MLC-responding cells. No specificity for this cell-dependent suppression could be determined. The inhibitory effects of the suppressing cells could be abrogated by moderate X-ray irradiation and significantly reduced by pretreating them with an anti-Ia-like antiserum and complement, Tin-human suppressor cell responsible for the observed effects therefore appears to carry determinants equivalent to the murine Ia alloantigens.