Characterization of IgD

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Abstract
Endogenous and surface labelling techniques were used on human lymphoid cells to characterize intracytoplasmic, membrane and secreted IgD. IgD synthesized by lymphocytes and inserted into the cell membrane displayed a single molecular form with the same mobiliiy in sodium dodecyl sulphate polyacrylamide gel eleclrophorcsis (SDS‐PAGE) as the previously described slow migrating serum IgDl. Plasma cells produced and secreted IgD1 and another IgD corresponding to the faster‐moving serum IgD2. Conversion of one molecular form into the other was never observed, thus indicating that neither molecule is a precursor or a degradation product of the other.