Nociceptin induced inhibition of K+ evoked glutamate release from rat cerebrocortical slices
Open Access
- 1 November 1996
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 119 (6) , 1081-1083
- https://doi.org/10.1111/j.1476-5381.1996.tb16007.x
Abstract
Nociceptin, an endogenous ligand for the orphan receptor ORL1, has recently been described. In this study we have shown that nociception inhibits 46 mM K+‐stimulated glutamate release from rat perfused cerebrocortical slices with an IC50 of 51 nM. At 100 nM the inhibition amounted to 68 ± 14% and was naloxone (10 μm)‐insensitive excluding an activation of μ, δ and κ opioid receptors. These data demonstrate the functional coupling of ORL1 in glutamatergic neurones and implicates a role for nociceptin in glutamatergic neurotransmission.Keywords
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