The fate of oxaloacetate in animal tissues

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Abstract
In pigeon breast muscle, sheep heart, and guinea-pig kidney, added oxaloacetate yields CO2, fumarate, malate, [alpha]-keto-glutarate, citrate, succinate and pyruvate (when the conditions are anaerobic). These substances account for all the added oxaloacetate. The quantities formed are in agreement with the citric acid cycle theory. Sheep testis and sheep brain also form citrate and [alpha]-ketoglutarate from oxaloacetate; and this in our opinion suggests that the citric acid cycle, or at least some of its component reactions, can occur in these tissues. But it is not yet possible to assess the quantitative significance of these reactions in the normal metabolism of brain and testis.

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