Effect of tritiated thymidine and 5-bromodeoxyuridine on development of immunologically competent lymphocytes.
- 1 January 1969
- journal article
- Vol. 16 (1) , 83-90
Abstract
Results of the present experiments suggest that dividing cells in rat bone marrow can generate lymphocytes capable of initiating a systemic graft-versus-host reaction. In these experiments, Lewis bone marrow cells were incubated in vitro with either tritiated thymidine ([3H]thymidine) or 5-bromodeoxyuridine (BUDR)—agents which inhibit cell proliferation. Bone marrow cells prepared in this way and injected into an intermediate (Lewis×DA)F1 host were unable to proliferate and mature into circulating immunologically competent lymphocytes.This publication has 10 references indexed in Scilit:
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