Complete amino acid sequence of a mouse mu chain: homology among heavy chain constant region domains

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Abstract
The complete amino acid sequence of the mouse .mu. chain secreted by the MOPC 104E myeloma tumor was determined. There are 4 constant region domains in the .mu. chain and a 20-residue COOH-terminal segment that plays a role in the polymerization of pentameric Ig M molecules. There are 6 sites of carbohydrate attachment in the MOPC 104E .mu. chain. Three complex-type and 2 high-mannose oligosaccharides are located in the .mu. chain constant region. The general type and location of carbohydrate moieties in the .mu. chain constant region are completely conserved between mouse and human .mu. chains. Homology in the location of carbohydrate structures on different classes of heavy chains is discussed.