The cyelodesulfurization of thio‐compounds. Part XVII. Synthesis of some novel 2‐substituted amino‐3,4‐dihydro‐5H‐1,3,4‐benzotriazepin‐5‐ones by cyelodesulfurization of thiosemicarbazides with dicyclohexylearbodiimide (DCCD)

Publisher Website
Google Scholar
Abstract
A simple method for the synthesis of a novel series of 2‐substituted amino‐3,4‐dihydro‐5H‐1,3,4‐benzotriazepin‐5‐ones (11–16) has been established through two routes. The first involving the cyelodesulfurization of the thiosemicarbazides (3–8) with DCCD and the second reacting mixtures of the acid hydrazide 1 with a variety of the isothiocyanates 2 and DCCD. The structure of the cyclized products was confirmed by nmr and mass spectra.