Comparison of Endogenous and Exogenous Creatinine Clearances in Man.

Publisher Website
Google Scholar
Abstract
Nine normal individuals and 6 patients with varying levels of renal insufficiency were given intravenous infusions of creatinine. The endogenous creatinine clearance: inulin clearance ratio in the normal subjects was 1.11. The ratio of the exogenous creatinine clearance to inulin clearance rose quickly to 1.73 as soonas the creatinine infusionwas started, then gradually fell to 1.40 after 90 rain, of infusion. The patients with renal insufficiency had an initial ratio of 1.50 and showed no abrupt rise when exogenous creatinine was infused. A late rise to 1.71 after 90 min. may not be significant. A small increment in the serum creatinine concentration may cause an increased effectiveness of the tubular mechanism for creatinine secretion. An alteration in the serum creatinine resulting in enhanced tubular transport, or reducing apparent serum creatinine concentration without affecting filtration, is less probable. The high pre-infusion ratio in patients with renal insufficiency, and their failure to respond to exogenous creatinine, suggests that once activated, the mechanism for increased tubular excretion may continue as long as the stimulus of an elevated serum creatinine persists.

This publication has 7 references indexed in Scilit: