Sinus Histiocytosis with Massive Lymphadenopathy: Virological, Immunological and Morphological Studies

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Abstract
Histiocytes from a patient with sinus histocytosis were tested for the presence of Epstein-Barr viral (EBV) nuclear antigen (EBNA) before and after in vitro growth. On both occasions, the histiocytes and lymphocytes were EBNA-negative. The profile of EBV viral capsid antibody [Ab] and (VCA) suggests that this virus may not be directly involved in the development of the disease. The maintenance of an unusually high level of Ab to EBV and measles, which produce persistent infections, indicates that the humoral immune response is active. A normal humoral response occurred in response to mumps virus during the same period. A deficiency in the cell mediated immune response to the persistent viruses might be the reason for the abnormally high Ab levels. The fresh and cultured histiocytes had only Fc receptors. The affected lymph node lymphocytes developed unusually large inclusion bodies following in vitro culture.