Modifications of Vestibulo-ocular Reflex Induced by Diazepam: Experiments in the Macaque
- 1 December 1979
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery
- Vol. 105 (12) , 698-701
- https://doi.org/10.1001/archotol.1979.00790240012003
Abstract
• The vestibulo-ocular reflex in the macaque was tested before and after intravenous administration of diazepam. The drug effect was marked by decrease in gain and increase in time constant of nystagmus in response to a modified Bárány test and by reduction in directional asymmetry of nystagmus. Because the time course of reduction in gain differed from the time course of increase in time constant, diazepam probably has more than one site of action. These results emphasize the complexity of neural processing in the vestibulo-ocular reflex arc. (Arch Otolaryngol 105:698-701, 1979)This publication has 6 references indexed in Scilit:
- Brain mechanisms associated with therapeutic actions of benzodiazepines: focus on neurotransmittersAmerican Journal of Psychiatry, 1977
- Functional organization of primate oculomotor system revealed by cerebellectomyExperimental Brain Research, 1974
- Drug Effects on Postlabyrinthectomy NystagmusJAMA Otolaryngology–Head & Neck Surgery, 1973
- Accommodation of the eye during sleep and anesthesiaVision Research, 1973
- Physiology of peripheral neurons innervating semicircular canals of the squirrel monkey. I. Resting discharge and response to constant angular accelerations.Journal of Neurophysiology, 1971
- VESTIBULO-OCULAR REFLEX ARCArchives of Neurology & Psychiatry, 1933