Studies on the Male Antifertility Agent - Gossypol Acetic Acid. V. Effect of Gossypol Acetic Acid on the Fertility of Male Rats

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Abstract
Gossypol acetic acid was given to male rats at a dose of 7.5 mg/rat per day 6 days a week for 10 wk. After 9 wk of gossypol treatment no implantation sites were observed in the females mated with gossypol treated males. After 10 wk of gossypol treatment all the spermatozoa in the vas deferens were non-motile. Gossypol treatment did not affect the body weight and the weights of the accessory sex organs. Plasma lutropin and FSH levels, human chorionic gonadotropin binding in testis and succinic dehydrogenase (SDH) and ATPase activities in liver, kidney and testis were not affected by gossypol treatment. Histological observations of the testis revealed partial damage to the seminiferous tubules. Single high doses of gossypol did not induce significant changes in the body weight and weights of testis and accessory sex organs. ATPase activity in the testis was reduced significantly after gossypol treatment, the enzyme activity in liver and kidney was, however, affected at high doses only. Gossypol treatment had no effect on the histoarchitecture of the testis. Intratesticular administration of gossypol evoked localized damage in the testis. Gossypol treatment had no effect on 125I FSH binding to the rat testis homogenate in vitro.