Transient appearance of CD3+CD8+ T lymphocytes with monoclonal gene rearrangement of T‐cell receptor β locus
Open Access
- 1 February 1998
- journal article
- case report
- Published by Wiley in British Journal of Haematology
- Vol. 100 (2) , 411-414
- https://doi.org/10.1046/j.1365-2141.1998.00555.x
Abstract
A benign, transient proliferation of atypical lymphocytes and a monoclonal rearrangement of the T‐cell receptor β (TRB) locus was found in a 60‐year‐old woman who presented with low‐grade fever, anorexia and fatigue. A marked and transient atypical lymphocytosis (white blood cell count 90.5 × 109/l) with CD8 surface antigen improved without specific treatment. Although tests for IgM antibodies to hepatitis A, varicella zoster, Epstein‐Barr virus (EBV), and cytomegalovirus (CMV) were all negative, a monoclonal gene rearrangement of TRB locus was observed in the DNA of the proliferated atypical lymphocytes by Southern blotting. The clonal rearrangement and the atypical lymphocytes disappeared after 14 d, and the patient has remained well for 7 years. These results suggest that monoclonal proliferation of CD8 lymphocytes can occur based on a non‐neoplastic aetiology.Keywords
This publication has 8 references indexed in Scilit:
- Oligoclonal T cell receptor gene rearrangements in blood lymphocytes of patients with acute Epstein-Barr virus-induced infectious mononucleosis.Journal of Clinical Investigation, 1990
- Detection of Epstein-Barr virus genome in benign polyclonal proliferative T cells of a young male patientBlood, 1990
- DNA segment containing C beta 1, a gene for the constant region of the beta chain of the T-cell antigen receptor, was inserted into chromosome 6 in cells from one patient with human T-cell leukemia.Proceedings of the National Academy of Sciences, 1987
- Genetic polymorphism and exon changes of the constant regions of the human T-cell rearranging gene gamma.Proceedings of the National Academy of Sciences, 1986
- Analysis of the transcript encoding the latent Epstein-Barr virus nuclear antigen I: a potentially polycistronic message generated by long-range splicing of several exons.Proceedings of the National Academy of Sciences, 1985
- Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease.Proceedings of the National Academy of Sciences, 1984
- Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins.Journal of Clinical Investigation, 1983
- Molecular cloning of the complete Epstein-Barr virus genome as a set of overlapping restriction endonuclease fragmentsNucleic Acids Research, 1981