Association Between Apolipoprotein E Genotype and Alzheimer Disease in African American Subjects

Open Access

1 April 2002

journal article
research article
Published by American Medical Association (AMA) in Archives of Neurology

Vol. 59 (4) , 594-600
https://doi.org/10.1001/archneur.59.4.594

Abstract

A GENETIC BASIS for Alzheimer disease (AD) is well established.¹ Survival analysis suggests that the risk for AD is 2 to 3 times higher among first-degree relatives of patients with AD compared with nonrelatives.² This trend is evident in multiple ethnic groups, including white,³^-5 Hispanic,⁶ and African American⁶^,7 subjects. Mutations in the amyloid precursor protein and presenilin 1 and 2 genes may be responsible for as much as 50% of familial (ie, autosomal dominant) AD beginning before 60 years of age¹^,8^-10; however, these defects have a low epidemiological impact, accounting for less than 1% of patients worldwide.¹¹

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