SERUM INORGANIC PHOSPHORUS LEVELS IN MALES AND FEMALES AT PROGRESSIVE AGES, WITH CONCOMITANT MEASUREMENTS OF URINARY KETOSTEROIDS AND ANDROGENS IN MEN*

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Abstract
Serum inorganic phosphorus (SIP) levels at progressive ages are described for each sex and analyzed with regard to variations from time to time in the same subjects and the range of values among subjects at progressive ages. Previous studies have shown that the SIP level tends to be high until the age of sexual maturation or shortly thereafter, and that in young adults an inverse relationship exists between gonadal secretions and values for SIP. Present data indicate that the extent of the influence of gonadal secretions upon SIP concentration decreases with age, apparently due in part to low values for SIP apart from the influence of gonadal secretions, and consequently, less opportunity for gonadal secretions to effect further reduction. Values for SIP are not correlated with urinary titers of ketosteroids and androgens, even in young men. This is in keeping with studies of secondary sex characters; the growth and maintenance of these characters are dependent upon stimulation by sex hormones, but the degree of their development is largely controlled by genetic factors and is not correlated significantly with values for urinary ketosteroids or androgens.

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