STUDIES OF CALCIUM AND PHOSPHORUS METABOLISM. XVI. THE INFLUENCE OF THE PITUITARY GLAND 1

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Abstract
In 5 patients with acromegaly, the Ca and P metabolism differs from that in normal individuals. The observed abnormally is characterized by greater urinary excretion of these minerals, although the blood and fecal Ca and P values are normal. These greater excretion rates roughly parallel the intensity of the disease, but are not dependent upon an elevated basal metabolic rate. Roentgen ray therapy of the pituitary gland caused a reduction in the urinary Ca and P excretion in 1 patient and was without effect in another. The adm. of Lugol''s soln. to 1 patient did not alter the basal metabolic rate nor the Ca and P metabolism. The ant. pituitary gland may therefore influence the Ca metabolism and no relationship with other glands of internal secretion has been established.

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