Fowl Cholera: Cross-Protection Induced by Pasteurella multocida Separated from Infected Turkey Blood

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Abstract
Crude liver homogenates from turkeys that died of fowl cholera produced by serotype 1 or 3 P. multocida induced cross-protection. P. multocida harvested from the blood of infected turkeys by a centrifugal technique were as immunogenic as the liver homogenates. Neither bacterial cell-free blood plasma or washed P. multocida from infected turkeys induced significant cross-protection. Blood plasma containing P. multocida induced significant cross-protection. P. multocida grown in the turkey underwent bacteriolysis after thawing from a frozen state. Filtered lysates did not induce cross-protection when used as vaccines whereas unfiltered lysates did. Membrane filters impeded passage of immunogenic material.