Detoxification of the organophosphorus insecticide chlorfenvinphos by rat, rabbit and human liver enzymes
- 1 January 1986
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 16 (1) , 87-93
- https://doi.org/10.3109/00498258609043509
Abstract
1. A good inverse correlation between the acute oral toxicity of chlorfenvinphos and its rate of oxidative detoxification in the liver exists for rats, mice, rabbits and dogs. 2. Measurements of the rates of oxidative metabolism (O-de-ethylation) by in vitro liver preparations from rat, rabbit and human have been compared. When the results are expressed in terms of cytochrome P450, as opposed to microsomal protein, detoxification by the human liver enzyme(s) is almost as effective as that by rabbit enzyme(s). 3. The rabbit is relatively resistant to the acute toxic action of the insecticide.This publication has 9 references indexed in Scilit:
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