Serum Acid Phosphatase and Screening for Carcinoma of the Prostate

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Abstract
In 1977 Foti et al.1 described a new radioimmunoassay for prostatic acid phosphatase in patients with carcinoma of the prostate, including a large number with disease in Stages A and B. (In Stage A, foci of tumor are found incidentally at prostatectomy for presumed benign obstruction. Stage B refers to biopsy-proved intracapsular tumor, usually detected by rectal examination and without evidence of metastases.) The previously available colorimetric or enzymatic assays for acid phosphatase had yielded values within normal limits in patients with localized prostatic cancer, but Foti el al. reported increased levels found by radioimmunoassay in 33 per cent of . . .