Reversing of chlorambucil resistance by ethacrynic acid in a B‐CLL patient
- 1 October 1993
- journal article
- case report
- Published by Wiley in British Journal of Haematology
- Vol. 85 (2) , 409-410
- https://doi.org/10.1111/j.1365-2141.1993.tb03187.x
Abstract
Summary We evaluated the reversing activity of ethacrynic acid in a B‐CLL patient resistant to chlorambucil. The glutathione S‐transferase (GST) activity, measured in peripheral blood lymphocytes, resulted extremely elevated. Etha crynic acid, at pharmacological concentrations, partially reversed chlorambucil resistance and this result appeared related to the increased GST levels.Keywords
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