The Potassium Concentration in Cerebrospinal Fluid in Young and Adult Rats Following Complete Brain Ischemia. Effects of Pretreatment with Hypoxia

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Abstract
The K+ concentration in the cisternal CSF was measured following brain ischemia in rats of different ages which were kept at normoxia or pretreated with hypoxia (PIO2 [partial pressure of O2 in inspired air] = 70 mmHg) for 24 h. In all age groups the K+ concentration rose following ischemia. The rate of rise was relatively slow in the 4 day rat and faster in 16 and 24 day rats; beyond this age the rate of rise became slower. Pretreatment with hypoxia significantly diminished the rate of rise in CSF K+ in 4 and 8 day rats, while no effect was observed in the older age groups. The rate of rise in CSF K+ is probably inversely correlated with the capacity of surviving a period of O2 deprivation.