CHLORPROMAZINE AND PROPRANOLOL EXTEND SURVIVAL OF INFANT MICE INOCULATED WITH ENTERO-TOXIGENIC ESCHERICHIA-COLI

  • 1 January 1981
    • journal article
    • research article
    • Vol. 12  (2) , 137-141
Abstract
Effects of chlorpromazine and propranolol were tested in an infant mice model of enterotoxigenic E. coli diarrhea. Reference strain B41, inoculated orally 18-48 h after birth, caused death of most animals in < 48 h. Both drugs, which are known to reverse submaximal induced secretion by heat-stable toxin in the suckling mouse assay (used as single treatment), were able to extend the survival of mice.