Hepatotoxic Effects of Sera from Patients with Fulminant Hepatitis B on Isolated Rat Hepatocytes in Culture

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Abstract
The hepatotoxicity of sera from patients with terminal fulminant hepatic failure was investigated by cell culture techniques. Untreated and heat-treated sera were cytotoxic. Compared with the action of sera from healthy individuals on liver cells in primary monolayer culture, the pathological sera exhibited significantly different effects on morphological and biochemical parameters such as cell adhesion, growth and proliferation and enzyme release.