Further Evidence of Immunologic Dissimilarity of Distemper (CD) and Measles (M) Viruses.

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Abstract
Additional experimental evidence of dissimilarity of canine distemper (CDV) and measles (MV) viruses are presented. Ferrets inoculated with repeated doses of MV-adjuvant mixture and which developed MV antibodies proved as susceptible as control animals to challenge with CDV. Paired convalescent sera from measles patients showed significant measles antibody rises, while CD antibodies remained essentially absent. Growth of MV in HeLa cells was not inhibited by presence of CD anti-serum or normal serum, while MV antiserum apparently reduced virus multiplication. Presence of measles antiserum did not interfere with propagation of CDV. By 14th day after MV infection, serologically negative monkeys developed high antibody titers for MV but none for CDV. It remains to be determined whether results obtained are attributable to particular virus strains used, or apply also to other isolates of MV and CDV.