CYCLIC ADENOSINE 3′, 5′‐MONOPHOSPHATE AND LEUCOCYTE CHEMOTAXIS in vivo

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Abstract
1 The effect of local elevation of leucocyte cyclic adenosine 3′, 5′-monophosphate (cyclic AMP) content on the continued migration of leucocytes to a site of acute inflammation was studied in the pleural cavity of rats. 2 Leucocyte cyclic AMP levels were elevated by injecting with the irritant into the pleural cavity dibutyryl cyclic AMP alone or with theophylline. 3 The treatments both produced a marked reduction in leucocyte migration into a pleural reaction induced by immediate hypersensitivity, but had no effect on cell numbers in pleurisy induced either by pyrophosphate or urate crystals.