Interaction of Felbamate with Several Other Antiepileptic Drugs Against Seizures Induced by Maximal Electroshock in Mice
- 1 March 1993
- Vol. 34 (2) , 367-371
- https://doi.org/10.1111/j.1528-1157.1993.tb02423.x
Abstract
Summary: The anticonvulsant effects of felbamate (FBM) alone or in combination with phenytoin (PHT), carbamazepine (CBZ), valproate (VPA), or phenobarbital (PB) were investigated against maximal electroshock (MES) seizures in mice. Nonprotective doses of the prototype antiepileptic drugs (AEDs) enhanced the protective effects of FBM against electrically induced seizures, as shown by significant reduction of FBM ED50 values. Toxicity as determined by rotorod test was not significantly potentiated, however, and the protective index (PI = TD50/ED50) of FBM was increased by >100% for each AED interaction. The increase in anticonvulsant potency of FBM after its combination with nonprotective doses of AEDs could not be accounted for by a pharmacokinetic mechanism.Keywords
This publication has 18 references indexed in Scilit:
- Effect of Non‐Sex Hormones on Neuronal Excitability, Seizures, and the ElectroencephalogramEpilepsia, 1991
- Interaction of felbamate and diazepam against maximal electroshock seizures and chemoconvulsants in micePharmacology Biochemistry and Behavior, 1991
- Overview of the Clinical Efficacy of LamotrigineEpilepsia, 1991
- Electroencephalographic Correlations of Extracranial and Epidural Electrodes in Temporal Lobe EpilepsyEpilepsia, 1991
- The role of radiation therapy following resection of single brain metastasis from melanomaNeurology, 1990
- Combined Administration of Carbamazepine and Phenobarbital: Effect on Anticonvulsant Activity and NeurotoxicityEpilepsia, 1988
- Involvement of a GABAergic mechanism in the anticonvulsant effect of pentobarbital against maximal electroshock-induced seizures in ratsPharmacology Biochemistry and Behavior, 1985
- Effect of Dopaminergic and GABA‐ergic Drugs Given Alone or in Combination on the Anticonvulsant Action of Phenobarbital and Diphenylhydantoin in the Electroshock Test in MiceEpilepsia, 1980
- Which Anticonvulsant Drug?Drugs, 1979
- A Note on a Simple Apparatus for Detecting Neurological Deficit in Rats and Mice**College of Pharmacy, University of Nebraska, Lincoln 8.Journal of the American Pharmaceutical Association (Scientific ed.), 1957