The synthesis of N(τ)-(2-hydroxypropyl)histidine, N(τ)-(2-hydroxyethyl)histidine, and their deuteriated analogues
- 1 January 1983
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 6,p. 1213-1217
- https://doi.org/10.1039/p19830001213
Abstract
The synthesis of N(τ)-(2-hydroxypropyl) histidine (1), N(τ)-(2-hydroxy[2H5]propyl) histidine (2), N(τ)-(2-hydroxyethyl) histidine (3), and N(τ)-(2-hydroxy[2H4]ethyl) histidine (4) by reaction of protected histidine derivatives with bromoacetone, bromo[2H5]acetone, 2-benzyloxyethyl toluene-p-sulphonate (17), and 2-benzyloxy[1,1,2,2-2H4]ethyl toluene-p-sulphonate (18), respectively, is described.This publication has 3 references indexed in Scilit:
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- A rapid, simple, and mild procedure for alkylation of phenols, alcohols, amides and acidsTetrahedron, 1979
- MONITORING AND RISK ASSESSMENT BY MEANS OF ALKYL-GROUPS IN HEMOGLOBIN IN PERSONS OCCUPATIONALLY EXPOSED TO ETHYLENE-OXIDE1978