The Use of Levo-Dromoran Tartrate (Levorphan Tartrate) for Relief of Postoperative Pain

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Abstract
IT HAS long been recognized that the spatial configuration of optically active compounds can exert an important influence on their pharmacologic action.1 Either the levorotatory or the dextrorotatory form of such compounds may have a greater pharmacodynamic effect on certain tissues than its optical antipode. Usually, the levorotatory isomers are more powerful, but sometimes — for example, with amphetamine2 or acetylmethadol3 — the dextroisomer has greater activity. Occasionally the activity of one of the isomers is negligible.4 In other cases competitive antagonism exists between the two isomers. This has been shown for Neo-Synephrine and Sympatol.2 Recently, a new synthetic, morphine-like . . .