PRESENCE IN MOUSE BONE-MARROW OF MEDIATOR-DEPENDENT CYTO-TOXIC EFFECTOR-CELLS AGAINST TUMORS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 53  (5) , 227-233
Abstract
The role of bone marrow cells as cytotoxic effector cells against tumor cells was examined in vitro. Bone marrow cells from normal C3H/He mice could lyse murine MM46 tumor cells in the presence of wheat germ agglutinin [WGA] or syngeneic antitumor antibody. Bone marrow cells alone did not cause lysis. Eleven other lectins (concanavalin A, phytohemagglutinin, pokeweed mitogen, Lens culinaris hemagglutinin, Ulex europaeus agglutinin, peanut agglutinin, Bandeiraea simplicifolia agglutinin, Bauhinia purpurea agglutinin, soybean agglutinin, Limulus polyphemus agglutinin and Helix aspersa agglutinin) did not induce cytolysis. Enrichment of polymorphonuclear leukocytes (PMN) by free flow electrophoresis enhanced the activity of WGA-dependent cytolysis. PMN series in the bone marrow of normal mice apparently can lyse tumor cells with appropriate mediators.