Effect of Charcoal Hemoperfusion on Amino Acid Disturbance in Experimental Hepatic Coma
- 1 July 1984
- journal article
- research article
- Published by SAGE Publications in The International Journal of Artificial Organs
- Vol. 7 (4) , 203-208
- https://doi.org/10.1177/039139888400700410
Abstract
Using the galactosamine induced hepatic coma rat model, we studied the effects of coated charcoal hemoperfusion on amino acids in plasma and CSF in grade III hepatic coma. We found that 1 hour of hemoperfusion significantly reduced AAAs and BCAAs in plasma and increased the molar ratio of BCAA:AAA. When rats in grade III coma were treated with 2 consecutive 1-hour hemoperfusions, the substantial reduction of plasma AAAs resulted in a significant decrease of AAA levels in CSF.Keywords
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