MICROTHROMBUS FORMATION ON HEMODIALYSIS MEMBRANES - A PLACEBO CONTROLLED RANDOMIZED TRAIL OF 2 DOSES OF INDOBUFEN

  • 1 January 1985
    • journal article
    • research article
    • Vol. 24  (1) , 31-36
Abstract
The role of indobufen in preventing the formation of microthrombi on hemodialysis membranes was investigated in 18 patients in a placebo controlled randomized double-blind cross-over study. All patients had been on regular maintenance hemodialysis for at least 3 mo. Indobufen was given as 100 mg bd [2 times/day] and 200 mg bd each for a 7 day period with a 7 day wash-out period between the treatments. Both indobufen regimens prevented the fall in platelet count, reduced the increase in plasma BTg levels during dialysis, increased the post dialysis plasma heparin levels (P < 0.05) and inhibited predialysis platelet aggregation with collagen (P < 0.05) when compared with placebo treatment. Scanning electron microscopy demonstrated minimal fibrin and reduced platelet deposition following indobufen treatment. There was no difference in the effect of 100 mg bd and 200 mg bd indobufen doses. The drug was well tolerated, despite the relatively high levels measured, only 1 patient withdrew because of side effects. Apparently, indobufen when added to a routine hemodialysis treatment schedule, can significantly reduce platelet activation and the thrombus formation on the hemodialysis membranes.