A QUANTITATIVE COMPARISON OF WHOLE ANTIBODY AND F(ab)2 IN KIDNEY ALLOGRAFT ENHANCEMENT1

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Abstract
Whole antiserum, IgG, and a >99% pure F(ab)2 preparation were compared for their ability to enhance Lewis renal allo-grafts in DA recipients. Despite having unimpaired antigen-binding capacity, the DA anti-Lewis F(ab)2 was virtually ineffective at the highest dose tested, and was calculated to be a minimum of 100 times less effective than whole antibody. The administration of a 10-fold excess of F(ab)2 before an effective dose of IgG did not block the enhancing effect of the latter.