THIOURACIL TREATMENT OF THYROTOXICOSIS

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Abstract
THE pronounced effectiveness of thiouracil1 in the control of thyrotoxicosis has been well established, but the types and frequency of toxic reactions to this drug have had relatively little discussion, because of the relatively small number of cases reported upon. In this study an analysis is made of 247 patients whom we have treated with thiouracil, as well as about 800 cases reported by others. It is hoped that by a better understanding of the toxic reactions this drug can be used more efficiently and safely. It is not possible to obtain from the reports in the literature the exact incidence of the various toxic reactions that have occurred. In some instances only the patients with toxic reactions are reported and in some the studies were terminated or pursued further depending upon whether the specific investigators had or had not encountered certain toxic reactions. The statistics dealing with the incidence of reactions given in this paper are based only on the reports that seem to present all of the patients with thyrotoxicosis treated with thiouracil.
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