Fetal Liver Transplantation in 2 Patients with Acute Leukaemia after Total Body Irradiation

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Abstract
Two patients with acute leukemia in relapse were transplanted with fetal liver cells following a conditioning regimen of cyclophosphamide (120 mg/kg) and total body irradiation (1000 rad). Each patient achieved a remission with hematopoietic recovery that was rapid in 1 case and delayed in the other. In 1 case there was evidence of chimerism as demonstrated by the presence of the XYY karyotype of the donor fetus in 20% of marrow metaphases, by the presence of double Y bodies in the peripheral blood, by the appearance of new HLA-antigens, and by red cell isoenzyme phenotypes of donor origin. In the 2nd case there was prompt hemotopoietic recovery and the appearance of red cell isoenzyme phenotypes of donor origin. Survival was 153 and 30 days, respectively, and both patients died of interstitial pneumonia without evidence of graft vs. host disese.