Pharmacokinetics and Bioavailability of a Metformin/Glyburide Tablet Administered Alone and with Food
- 1 December 2000
- journal article
- clinical trial
- Published by Wiley in The Journal of Clinical Pharmacology
- Vol. 40 (12) , 1494-1502
- https://doi.org/10.1177/009127000004001222
Abstract
Two randomized crossover studies were conducted to evaluate the pharmacokinetics (including food effect) of fixed‐combination metformin/glyburide tablets. Pharmacokinetics and bioavailability of two strengths (500 mg/2.5 mg and 500 mg/5 mg) of metformin/glyburide tablets were assessed relative to coadministered metformin and glyburide tablets in study 1. The effect of a high‐fat meal on the bioavailability of a metformin/glyburide (500 mg/5 mg) tablet was assessed relative to the fasted condition in study 2. The fixed combination metformin/glyburide tablets showed bioequivalence for the metformin component with the reference metformin tablet and comparable bioavailability for the glyburide component with the reference glyburide tablet. Food does not appear to affect the bioavailability of either component to an appreciable extent.Keywords
This publication has 10 references indexed in Scilit:
- Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin HC1 in manBritish Journal of Clinical Pharmacology, 1996
- Efficacy of Metformin in Patients with Non-Insulin-Dependent Diabetes MellitusNew England Journal of Medicine, 1995
- A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo BioavailabilityPharmaceutical Research, 1995
- What Is the Benefit of Increasing the Sulfonylurea Dose?Annals of Internal Medicine, 1993
- Pharmacokinetic and pharmacodynamic studies of glibenclamide in non‐ insulin dependent diabetes mellitus.British Journal of Clinical Pharmacology, 1990
- The effect of in-vivo dispersion and gastric emptying on glibenclamide absorption from a novel, rapidly dissolving capsule formulationJournal of Pharmacy and Pharmacology, 1984
- PharmacokineticsPublished by Taylor & Francis ,1982
- Impaired effect of sulfonylurea following increased dosageEuropean Journal of Clinical Pharmacology, 1982
- Metformin kinetics in healthy subjects and in patients with diabetes mellitus.British Journal of Clinical Pharmacology, 1981
- Comparative Single‐Dose Kinetics and Effects of Four Sulfonylureas in Healthy VolunteersActa Medica Scandinavica, 1980