Kinetics of201T1 Uptake in Adenomas and Well-Differentiated Carcinomas of the Thyroid a Double Isotope Investigation with99Tcmand201T1

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Abstract
A visually increased uptake of 201TI chloride corresponding to a ‘cold’ (131I or 99Tcm) thyroid nodule is mostly seen in well-differentiated carcinomas but also often in follicular adenomas. Since a visually increased uptake of 201Tl can be due to an increased initial uptake and/or a delayed elimination, an extended dynamic investigation was performed in patients with well-differentiated carcinomas or with follicular adenomas. Data were collected in a dynamic simultaneous double isotope (99Tcm+201Tl) study up to 50 min after intravenous administration. Adenomas could be significantly separated from carcinomas by the elimination (p=0.0001), but not by the initial uptake.