A gene homologous to the reg gene is expressed in the human pancreas
- 2 August 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 327 (3) , 289-293
- https://doi.org/10.1016/0014-5793(93)81006-l
Abstract
We have determined the nucleotide sequence of reg1 a human genomic DNA fragment homologous to the reg gene which is expressed in the exocrine pancreas and regenerating islets. Sequence comparisons of reg and reg1 suggested similar exonintron organisation. Based on this assumption, specific oligonucleotides for reg1 exons were used to demonstrate expression of the reg1 gene in pancreas and liver. The proteins encoded by reg and reg1 comprise 166 amino acids and differ by 22 amino acids only.Keywords
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