Fibromyalgia and major affective disorder: a controlled phenomenology and family history study

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Abstract
Fibromyalgia is a form of nonarticular rheumatism characterized by diffuse musculoskeletal pain. To investigate the relationship between fibromyalgia and major affective disorder, 31 patients with fibromyalgia and 14 patients with rheumatoid arthritis were evaluated for rates of current or past major affective disorder and family history of major affective disorder. Both the rate of major affective disorder and the familial prevalence of major affective disorder were significantly higher in the fibromyalgia patients than the rheumatoid arthritis patients. Fibromyalgia may be related to major affective disorder.