IMMUNOGLOBULIN-A ANTI-GLIADIN ANTIBODIES IN CELIAC-DISEASE

  • 1 January 1981
    • journal article
    • research article
    • Vol. 46  (2) , 286-293
Abstract
Sixty-two sera from children under investigation for gastrointestinal disease were tested for IgA, IgG and IgM antibodies to gliadin by the following 2 different methods: an immunofluorescent (IF) test and a mixed reverse (solid-phase) passive antiglobulin hemadsorption (MRSPAH) test. There was good agreement between the tests. Both tests detected gliadin antibodies of IgG and IgA class in sera from children with active celiac disease, which tended to disappear when a strict gluten-free diet was instituted. Serum antibodies to gliadin of IgA class were associated with severe small intestinal villous atrophy and were found almost exclusively in celiac disease. Gliadin antibodies of IgG class were less disease-specific and were occasionally detected in sera from children with gastrointestinal disease other than celiac disease, notably in sera from children with transient gluten intolerance.