Effects of 4‐aminopyridine in experimental CNS demyelination
- 1 December 1988
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 38 (12) , 1884
- https://doi.org/10.1212/wnl.38.12.1884
Abstract
We studied the effect of systemically administered 4-aminopyridine in a model of CNS demyelination. In five rats with demyelination, slowed conduction velocity through the lesion was partially reversed at dose levels of 5.6 to 7.2 mg/kg. All rats developed convulsion at this dosage, and impaired conduction of high-frequency impulses was unchanged. These findings suggest certain limitations of 4-aminopyridine as a therapeutic agent.This publication has 8 references indexed in Scilit:
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