Premature centromere division: A possible manifestation of chromosome instability
- 13 March 1995
- journal article
- case report
- Published by Wiley in American Journal of Medical Genetics
- Vol. 56 (1) , 76-79
- https://doi.org/10.1002/ajmg.1320560117
Abstract
Retrospective analysis of “routine” chromosome preparations from 2 patients with Fanconi anemia and 2 others with ataxia‐teleangiectasia showed increased chromosome breakage and a tendency to premature centromere division (PCD) with special reference to early separation of the large aero‐centric (13–15) chromosomes. The findings suggest that PCD may be a manifestation of chromosome instability related to potential malignancy.Keywords
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