Is ZFY the sex-determining gene on the human Y chromosome?
- 1 December 1988
- journal article
- research article
- Published by The Royal Society in Philosophical Transactions of the Royal Society of London. B, Biological Sciences
- Vol. 322 (1208) , 155-157
- https://doi.org/10.1098/rstb.1988.0123
Abstract
The sex-determining region of the human Y chromosome contains a gene, ZFY , that encodes a zinc-finger protein. ZFY may prove to be the testis-determining factor. There is a closely related gene, ZFX , on the human X chromosome. In most species of placental mammals, we detect two ZFY -related loci: one on the Y chromosome and one on the X chromosome. However, there are four ZFY -homologous loci in mouse: Zfy-1 and Zfy-2 map to the sex-determining region of the mouse Y chromosome, Zfx is on the mouse X chromosome, and a fourth locus is autosomal.This publication has 8 references indexed in Scilit:
- The sex-determining region of the human Y chromosome encodes a finger proteinCell, 1987
- ‘Zinc fingers’: a novel protein motif for nucleic acid recognitionTrends in Biochemical Sciences, 1987
- A DELETION MAP OF THE HUMAN Y-CHROMOSOME BASED ON DNA HYBRIDIZATION1986
- Sex Reversal: Deletion Mapping the Male-determining Function of the Human Y ChromosomeCold Spring Harbor Symposia on Quantitative Biology, 1986
- Male sexual differentiation in mice lacking H–Y antigenNature, 1984
- Meitoic crossing-over between the X and Y chromosomes of male mice carrying the sex-reversing (Sxr) factorNature, 1982
- Mus poschiavinus Y Chromosome in the C57BL/6J Murine Genome Causes Sex ReversalScience, 1982
- Sex reversal in the mouse (Mus musculus) is caused by a recurrent nonreciprocal crossover involving the X and an aberrant Y chromosomeCell, 1982