The Mode of Antiarrhythmic Action of Melperone

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Abstract
The antiarrhythmic action of melperone was studied by His bundle electrography combined with programmed electrical stimulation in 21 pentobarbital anesthetized dogs. Melperone alone (0.5-12.5 mg/kg) as well as melperone after sympathetic and parasympathetic blockade caused a dose-dependent increase in the ventricular and the atrial effective refractory period without affecting atrial and ventricular conduction times. Melperone shortened the atrioventricular nodal conduction time regardless of sympathetic and parasympathetic blockade. The antiarrhythmic effect of melperone is most likely primarily due to a direct class III antiarrhythmic action.