Synthesis of nuclelc acid methylphosphonothloates

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Abstract
The reagent obtained in situ by treating methylphosphonothioic dichloride with 1-hydroxy-6-trifluromethylbenzotriazole could be used for the introduction of methylphosphonothioate linkages. The individual diastereomers of the protected dimer d-Tp(S,Me)A were applied in the synthesis of the chiral pure (R or S) hexamers d-[CpCpTp(S,Me)ApGpG]. The reagent showed also to be very effective for the preparation of the 3'',5''-cyclic methylphosphonothioate of uridine.