Histogenesis of microscopic adenoma and hyperplastic (metaplastic) gland in nonpolyposis coli

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Abstract
Histogenesis of microscopic adenoma in nonpolypoid [human] colons (those not included in the special disease group of familial polyposis coli) was investigated using complete serial sections with the following results: adenoma arises from basal cells in the deep layer of the mucosa and 2 types of basal cells found were: those which had already undergone changes to adenoma and those which are in their transitional stage to adenomas. Early phase growth of adenoma is brought about by branching. Individual hyperplastic (metaplastic) glands constituting so-called hyperplastic (metaplastic) polyps are apparently only an expression of 1 variant in the growing process of adenomas and the glands showing these changes most characteristically have a serrated pattern. The histogenesis of adenoma in nonpolypoid colons is schematically shown.