Pregnancy Enzymes and Placental Polymorphism: II. Leucine Aminopeptidase

Abstract
Variations in leucine aminopeptidase (LAP) were studied in the sera of 331 pregnant women and in a series of 219 placentas. No electrophoretic variations were found in the LAP pregnancy enzymes (oxytocinase). The pregnancy enzymes are probably not derived from the placenta. The placental extracts show 4 different LAP zones. Variations in 2 of these enzymes allow a division into 3 placental LAP types. No significant association was found between these LAP types and sex, birth order, placental weight, birth weight, gestation time and ABO and Rh blood groups. The importance of placental polymorphisms as an expression of the fetal genotype was discussed.

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