INTERFERON INHIBITION OF LYMPHOCYTE MITOGENESIS
- 1 January 1977
- journal article
- research article
- Vol. 33 (3) , 313-319
Abstract
Interferon inhibits the early phase of mitogenic action of concanavalin A on [mouse] lymphocytes as measured by incorporation of labeled precursors in RNA, DNA or protein. There was no evidence for a role of cyclic AMP in the inhibition process. Dialysis of interferon against high salt and urea did not separate cell inhibitory activity from antiviral [bovine vesicular stomatitis virus] activity. These results are compatible with the possibility that the antiviral and cell inhibitory activities are in the same molecule.This publication has 19 references indexed in Scilit:
- Reciprocal changes in interferon production and immune responses of mouse spleen cells fractionated over columns of insolubilized conjugates of histamineCellular Immunology, 1977
- Cyclic GMP stimulates lymphocyte nucleic acid synthesisNature, 1974
- Effects of Interferon on Antibody Synthesis in VitroThe Journal of Immunology, 1974
- Suppression of Mouse Antibody Producing Spleen Cells by Various Interferon PreparationsNature, 1973
- Effects of Interferon on Leukaemia Virus Activation in Graft versus Host DiseaseNature New Biology, 1973
- Induction of Cytolysis of Cultured Lymphoma Cells by Adenosine 3′:5′-Cyclic Monophosphate and the Isolation of Resistant VariantsProceedings of the National Academy of Sciences, 1973
- Interferon inhibits DNA Synthesis induced in Mouse Lymphocyte Suspensions by Phytohaemagglutinin or by Allogeneic CellsNature New Biology, 1972
- Interferon and cyclic-3′5′-adenosine monophosphate: Potentiation of antiviral activityBiochemical and Biophysical Research Communications, 1969
- Interferon-stimulating and in vivo antiviral effects of various synthetic anionic polymersVirology, 1968
- Inhibition of TRIG Agents by Virus-Induced Interferon.Experimental Biology and Medicine, 1966