Three different classes of oral antidiabetic drugs do not increase insulin binding and insulin-inducedRNA synthesis in human fibroblast cultures

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Abstract
We describe insulin binding and insulin-mediated RNA synthesis on seven human fibroblasts strains in culture initiated from skin biopsies in the presence of three oral antidiabetic agents, Metformin, Gliquidone, and a non-sulfonylurea antidiabetic drug (B × DF 591 ZW), which belong to different chemical classes. At least at a nontoxic pharmacologic concentration of 1 µg/ml these drugs did not influence the number and affinity of insulin receptors, nor did they increase the insulin-mediated RNA synthesis. We conclude that cultured fibroblasts do not represent the proper target for an evaluation of an extrapancreatic action of oral antidiabetic drugs.