Comparison of Interferon Action in Interferon Resistant and Sensitive L1210 Cells
- 1 October 1978
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 41 (1) , 161-166
- https://doi.org/10.1099/0022-1317-41-1-161
Abstract
Summary Translation inhibition, leu-tRNA aminoacylation and double-stranded RNA and ATP dependent phosphorylation were examined in interferon-treated and control cell-free lysates of leukaemic mouse L 1210 R and L 1210 S cells. No differences were observed between the respective interferon-treated and control cell-free extracts, except for the presence of an enhanced 67K dalton phosphoprotein fraction in interferon-treated L 1210 S cell-free extracts. In non-responding cell-free lysates, the lack of stimulation of a 67K dalton phosphoprotein fraction cannot be explained by the presence of an increased level of some inhibitory activity, such as a phosphatase.This publication has 3 references indexed in Scilit:
- Characteristics of Extracts from Interferon-treated HeLa Cells: Presence of a Protein Kinase and Endoribonuclease Activated by Double-stranded RNA and of an Inhibitor of mRNA MethylationJournal of General Virology, 1977
- Interferon, double-stranded RNA, and protein phosphorylation.Proceedings of the National Academy of Sciences, 1976
- Interferon Treatment of Ehrlich Ascites Tumor Cells: Effects on Exogenous mRNA Translation and tRNA Inactivation in the Cell ExtractJournal of Virology, 1976